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Thursday, June 20, 2019

When Stephen Fesik left the pharmaceutical industry to launch an academic drug-discovery laboratory, he drew up a wanted list of five of the most important cancer-causing proteins known to science. These proteins drive tumour growth but have proved to be a nightmare for drug developers: they are too smooth, too floppy or otherwise too finicky for drugs to bind to and block. In the parlance of the field, they are 'undruggable'.

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In August 2014, officials from the World Health Organization (WHO) called global-health specialist Adrian Hill, who is the director of a non-profit vaccine-research centre. They had an urgent question: how soon could the centre launch a clinical trial for an Ebola vaccine?

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In July 2010, the Chinese government sent a chill through the world's high-technology industries when it announced a 37% cut in export quotas for rare-earth elements — a group of 17 metallic elements that are essential ingredients in display screens, low-energy lighting, high-powered lasers and a host of other twenty-first-century products.

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Eli Bressert planned to spend his academic career in search of forming stars. He had completed a PhD in astronomy at the University of Exeter, UK, and had won a prestigious postdoctoral fellowship to study radio astronomy near Sydney, Australia. Citations of his papers and invitations for collaborations and conference talks were on the rise. He had no reason to want to work outside astronomy.

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